Why are antiepileptic drugs used for nonepileptic conditions?
نویسندگان
چکیده
منابع مشابه
Stopping Antiepileptic Drugs: When and Why?
After a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the bias towards continuing therapy indefinitely can be substantial. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs, but there are many benefits to AED withdrawal that should be evaluated on an ind...
متن کاملAre newer antiepileptic drugs associated with improved safety in pregnancy compared to older antiepileptic drugs?
Commentary As a group, antiepileptic drugs (AEDs) are associated with an increased risk of major congenital malformations (MCMs) (1). Older AEDs are the best studied. Valproate (VPA) is consistently associated with an increased risk of MCMs including an increased risk of spina bifida (2). Phenobarbital (PB) exposure increases the risk of MCMs, including oral clefts (3). Although not consistent ...
متن کاملNew antiepileptic drugs that are second generation to existing antiepileptic drugs.
In the last decade, 10 new antiepileptic drugs (AEDs) have been introduced that offer appreciable advantages in terms of their favourable pharmacokinetics, improved tolerability and lower potential for drug interactions. However, despite the large therapeutic range of old and new AEDs, approximately 30% of the patients with epilepsy are still not seizure free and, consequently, there is a subst...
متن کاملAnimal models used in the screening of antiepileptic drugs.
The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. These models can be either in vivo or in vitro, mechanism specific, mechanism independent, or seizure specific. To be predictive of therapeutic activity in patients, the models should approximate the events that precipitate seizures in humans. Model validation is defined by deter...
متن کاملOld versus New: Why Do We Need New Antiepileptic Drugs?
Achieving complete seizure remission without adverse events is the goal of epilepsy treatment. Recently, many new antiepileptic drugs (AEDs) have been developed. Even though the efficacy of new AEDs is not stronger than that of old AEDs, there are advantages in using new AEDs. They have unique or different mechanisms of action that enable the creation of possible synergistic combinations. They ...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2012
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2012.03712.x